Obesity is the most common medical condition in women of reproductive age. Obesity during
pregnancy has short term and long term adverse consequences for both mother and child …

Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

Appropriate in utero growth is essential for offspring development and is a critical contributor
to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal …

Maternal obesity is associated with placental lipotoxicity, oxidative stress, and inflammation,
where MAPK activity may play a central role. Accordingly, we have previously shown that …

The recent and rapid worldwide increase in non-communicable diseases challenges the
assumption that genetic factors are the primary contributors to such diseases. A new concept …

Context: Babies of obese women are often large at birth, which is associated with perinatal
complications and metabolic syndrome later in life. The mechanisms linking maternal …

Intrauterine growth restriction refers to the inability of the fetus to reach its genetically
determined potential size. Fetal growth restriction affects approximately 5–15% of all …

There is increasing recognition that maternal glucose concentrations lower than those
previously used for diagnosis of gestational diabetes mellitus (GDM) and targeted for …

Mammalian embryos have evolved to adjust their organ and tissue development in
response to an atypical environment. This adaptation, called phenotypic plasticity, allows the …