The rise in prevalence of obesity in women of reproductive age in developed and
developing countries might propagate intergenerational cycles of detrimental effects on …

Calcitriol and transforming growth factor beta 1 (TGF-β1) are unrelated molecules that
regulate biological processes according to the genetic target, cell type, and context. Several …

The prevalence of childhood obesity is increasing worldwide, and the children of women
who are obese during pregnancy are at greatest risk. This risk may be mediated by …

Fetal growth and development are dependent on placental nutrient transport. The
syncytiotrophoblast (ST) and its two polarized plasma membranes, the maternal-facing …

Epidemiologic studies identified the linkage between exposures to stresses, including the
type and plane of nutrition in utero with development of disease in later life. Given the critical …

Background The role of maternal serum triglycerides (TGs) in the development of fetal
macrosomia in different subgroups of body mass index (BMI) has received little attention …

The fetus is dependent on delivery of fatty acids (FAs) by the syncytiotrophoblast, the
transporting epithelium of the human placenta. Obese pregnant women have dyslipidemia; …

The incidence of pediatric nonalcoholic fatty liver disease has increased dramatically, and
growing evidence indicates that the pathophysiology may be unique from the adult form …

Context Intrauterine growth restriction (IUGR) is an immediate outcome of an adverse womb
environment, exposing newborns to developing cardiometabolic disorders later in life …

Background Metabolic changes in obese pregnant women, such as changes of plasma
lipids beyond physiological levels, may subsequently affect fetal development in utero …