[HTML][HTML] PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …
processes, including the regulation of transcription, apoptosis and the DNA damage …
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
G Hoxhaj, BD Manning - Nature Reviews Cancer, 2020 - nature.com
The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …
proliferation and survival. In normal cells, signal transduction pathways control core cellular …
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer
A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy
N Vasan, LC Cantley - Nature Reviews Clinical Oncology, 2022 - nature.com
Numerous agents targeting various phosphatidylinositol 3-kinase (PI3K) pathway
components, including PI3K, AKT and mTOR, have been tested in oncology clinical trials …
components, including PI3K, AKT and mTOR, have been tested in oncology clinical trials …
[HTML][HTML] The PI3K pathway in human disease
DA Fruman, H Chiu, BD Hopkins, S Bagrodia… - Cell, 2017 - cell.com
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …
Clinical implications of PTEN loss in prostate cancer
T Jamaspishvili, DM Berman, AE Ross, HI Scher… - Nature Reviews …, 2018 - nature.com
Genomic aberrations of the PTEN tumour suppressor gene are among the most common in
prostate cancer. Inactivation of PTEN by deletion or mutation is identified in∼ 20% of …
prostate cancer. Inactivation of PTEN by deletion or mutation is identified in∼ 20% of …
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
LM Thorpe, H Yuzugullu, JJ Zhao - Nature Reviews Cancer, 2015 - nature.com
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …
[HTML][HTML] Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
L Merkens, V Sailer, D Lessel, E Janzen… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …
The PI3K/AKT/mTOR interactive pathway
T Ersahin, N Tuncbag, R Cetin-Atalay - Molecular BioSystems, 2015 - pubs.rsc.org
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR)
signalling pathway is hyperactivated or altered in many cancer types and regulates a broad …
signalling pathway is hyperactivated or altered in many cancer types and regulates a broad …
Targeting senescence as an anticancer therapy
L Bousset, J Gil - Molecular Oncology, 2022 - Wiley Online Library
Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …