Substance P is a peptide mainly secreted by neurons and is involved in many biological
processes, including nociception and inflammation. Animal models have provided insights …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Abstract TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory
neurons. However, its role in other cell types is poorly understood. Here we found that …

Evolution has yielded multiple complex and complementary mechanisms to detect
environmental danger and protect tissues from damage. The nervous system rapidly …

Nociceptors and immune cells both protect the host from potential threats to homeostasis.
There is growing evidence for bidirectional signalling between these two systems, and the …

Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …

The nervous system and the immune system are the principal sensory interfaces between
the internal and external environment. They are responsible for recognizing, integrating, and …

Background Chili peppers are commonly consumed spices worldwide and capsaicin is the
main source for the spicy flavors, which is reported to have many biological activities …

BACKGROUND & AIMS: The neuropeptides calcitonin gene-related peptide (CGRP) and
substance P, and calcium channels, which control their release from extrinsic sensory …

We demonstrate a novel dual strategy against inflammation and pain through body-wide
desensitization of nociceptors via TRPA1. Attenuation of experimental colitis by capsazepine …