Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Background The bedaquiline–pretomanid–linezolid regimen has been reported to have
90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events …

The discovery of antibiotics in the previous century lead to reduction in mortality and
morbidity due to infectious diseases but their inappropriate and irrational use has resulted in …

To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …

Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

La introducción de los antibióticos en la práctica clínica supuso una de las intervenciones
más importantes para el control de las enfermedades infecciosas. Los antibióticos han …

Background. The threat of contagious infectious diseases is constantly evolving as
demographic explosion, travel globalization, and changes in human lifestyle increase the …

Highlights•Management of tuberculosis is complicated by high levels of drug resistance in
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …

Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …