The human female reproductive lifespan significantly diminishes with age, leading to
decreased fertility, reduced fertility quality and endocrine function disorders. While many …

Advanced maternal age is a major cause of infertility, miscarriage, and congenital
abnormalities. This is principally caused by a decrease in oocyte quality and developmental …

Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a
pivotal role in meeting the energy requirements of cells through the respiratory chain located …

Mitochondrial dysfunction is widely implicated in various human diseases, through
mechanisms that go beyond mitochondria's well-established role in energy generation …

Oxidative stress, a key factor in the aging process, has been increasingly recognized as
playing a critical role in ovarian aging (Yan et al., 2022). The accumulation of reactive …

Caffeine (1, 3, 7-trimethylxanthine) is a widely consumed bioactive substance worldwide.
Our recent study showed that a reduction in both reproduction and yolk protein production …

Oocyte cryopreservation is offered to women of various age groups for both health and
social reasons. Oocytes derived from either controlled ovarian stimulation or in vitro …

Post-ovulatory aging (POA) is an inevitable factor during some assisted reproduction
technology procedures, and results in poor fertilization rates and impaired embryo …