Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using
computational predictions from primary structures, complements secondary and tertiary …

Mutations in the BRCA1 and BRCA2 genes predispose afflicted individuals to breast,
ovarian, and other cancers. The BRCA-encoded products form complexes with other tumor …

Mutations in breast cancer type 1 susceptibility protein (BRCA1) and its heterodimeric
binding partner BARD1 confer a high risk for the development of breast and ovarian …

Breast and ovarian cancer represent two of the most common tumor types in females
worldwide. Over the years, several non‑modifiable and modifiable risk factors have been …

Cellular oxidative stress plays a vital role in the pathological process of neural damage in
cerebral ischemia/reperfusion (I/R). The breast cancer susceptibility protein 1 (BRCA1), a …

Abstract R-loops are RNA: DNA hybrids assembled during biological processes but are also
linked to genetic instability when formed out of their natural context. Emerging evidence …

Cancer is characterized by alterations that cause the over-proliferation of cells and
hyperactivation of signaling pathways. Alterations of signaling molecules dysregulate …

BRCA1-associated basal-like breast cancer originates from luminal progenitor cells. Breast
epithelial cells from cancer-free BRCA1 mutation carriers are defective in luminal …

Prostate cancer is among the most common diseases worldwide. Despite recent progress
with treatments, patients with advanced prostate cancer have poor outcomes and there is a …

In human cells homologous recombination (HR) is critical for repair of DNA double strand
breaks (DSBs) and rescue of stalled or collapsed replication forks. HR is facilitated by …