[HTML][HTML] Cellular senescence and senolytics: the path to the clinic

S Chaib, T Tchkonia, JL Kirkland - Nature medicine, 2022 - nature.com
Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

[HTML][HTML] Challenges in developing Geroscience trials

Y Rolland, F Sierra, L Ferrucci, N Barzilai… - Nature …, 2023 - nature.com
Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …

Therapy-induced senescence: opportunities to improve anticancer therapy

PG Prasanna, DE Citrin, J Hildesheim… - JNCI: Journal of the …, 2021 - academic.oup.com
Cellular senescence is an essential tumor suppressive mechanism that prevents the
propagation of oncogenically activated, genetically unstable, and/or damaged cells …

Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care

JE Carroll, JE Bower, PA Ganz - Nature Reviews Clinical Oncology, 2022 - nature.com
A growing body of evidence indicates that patients with cancer who receive cytotoxic
treatments (such as chemotherapy or radiotherapy) have an increased risk of accelerated …

Cellular senescence in skin‐related research: targeted signaling pathways and naturally occurring therapeutic agents

A Dańczak‐Pazdrowska, J Gornowicz‐Porowska… - Aging …, 2023 - Wiley Online Library
Despite the growing interest by researchers into cellular senescence, a hallmark of cellular
aging, its role in human skin remains equivocal. The skin is the largest and most accessible …

Physical activity intervention benefits persist months post-intervention: randomized trial in breast cancer survivors

LQ Rogers, KS Courneya, RA Oster, PM Anton… - Journal of Cancer …, 2023 - Springer
Purpose Determine durable effects of the 3-month Better Exercise Adherence after
Treatment for Cancer (BEAT Cancer) physical activity (PA) behavior change intervention 12 …

Leveraging spaceflight to advance cardiovascular research on earth

JM Scott, J Stoudemire, L Dolan, M Downs - Circulation research, 2022 - Am Heart Assoc
The direct (eg, radiation, microgravity) and indirect (eg, lifestyle perturbations) effects of
spaceflight extend across multiple systems resulting in whole-organism cardiovascular …

Aging and its treatment with vitamin C: a comprehensive mechanistic review

S Mumtaz, S Ali, HM Tahir, SAR Kazmi… - Molecular biology …, 2021 - Springer
Aging and age-related disorders have become one of the prominent issue of world.
Oxidative stress due to overproduction of reactive oxygen species is the most significant …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …

Applying a life course biological age framework to improving the care of individuals with adult cancers: review and research recommendations

JS Mandelblatt, TA Ahles, ME Lippman, C Isaacs… - JAMA …, 2021 - jamanetwork.com
Importance The practice of oncology will increasingly involve the care of a growing
population of individuals with midlife and late-life cancers. Managing cancer in these …