Emerging evidence for astrocyte dysfunction in schizophrenia

EC de Oliveira Figueiredo, C Calì, F Petrelli, P Bezzi - Glia, 2022 - Wiley Online Library
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

A review on the computational approaches for gene regulatory network construction

LE Chai, SK Loh, ST Low, MS Mohamad… - Computers in biology …, 2014 - Elsevier
Many biological research areas such as drug design require gene regulatory networks to
provide clear insight and understanding of the cellular process in living cells. This is …

Genome-wide association study identifies five new schizophrenia loci

Nature genetics, 2011 - nature.com
We examined the role of common genetic variation in schizophrenia in a genome-wide
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …

Identification of common variants associated with human hippocampal and intracranial volumes

JL Stein, SE Medland, AA Vasquez, DP Hibar… - Nature …, 2012 - nature.com
Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

[HTML][HTML] Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

[PDF][PDF] Astrocyte-secreted glypican 4 regulates release of neuronal pentraxin 1 from axons to induce functional synapse formation

I Farhy-Tselnicker, ACM van Casteren, A Lee… - Neuron, 2017 - cell.com
The generation of precise synaptic connections between developing neurons is critical to
the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of …

[HTML][HTML] MiR-137: an important player in neural development and neoplastic transformation

E Mahmoudi, MJ Cairns - Molecular psychiatry, 2017 - nature.com
MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …

[HTML][HTML] Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects

NR Smalheiser, G Lugli, H Zhang, H Rizavi, EH Cook… - PloS one, 2014 - journals.plos.org
Because of the role played by miRNAs in post-transcriptional regulation of an array of
genes, their impact in neuropsychiatric disease pathophysiology has increasingly been …

[HTML][HTML] Genome-wide association study meta-analysis of suicide death and suicidal behavior

QS Li, AA Shabalin, E DiBlasi, S Gopal… - Molecular …, 2023 - nature.com
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …

Synaptic elimination in neurological disorders

PL Cardozo, I de Lima, E Maciel… - Current …, 2019 - ingentaconnect.com
Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …