Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
A review on the computational approaches for gene regulatory network construction
LE Chai, SK Loh, ST Low, MS Mohamad… - Computers in biology …, 2014 - Elsevier
Many biological research areas such as drug design require gene regulatory networks to
provide clear insight and understanding of the cellular process in living cells. This is …
provide clear insight and understanding of the cellular process in living cells. This is …
Genome-wide association study identifies five new schizophrenia loci
Nature genetics, 2011 - nature.com
We examined the role of common genetic variation in schizophrenia in a genome-wide
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …
Identification of common variants associated with human hippocampal and intracranial volumes
Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …
Astrocyte-secreted glypican 4 regulates release of neuronal pentraxin 1 from axons to induce functional synapse formation
I Farhy-Tselnicker, ACM van Casteren, A Lee… - Neuron, 2017 - cell.com
The generation of precise synaptic connections between developing neurons is critical to
the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of …
the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of …
MiR-137: an important player in neural development and neoplastic transformation
E Mahmoudi, MJ Cairns - Molecular psychiatry, 2017 - nature.com
MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …
Genome-wide association study meta-analysis of suicide death and suicidal behavior
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …
Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects
NR Smalheiser, G Lugli, H Zhang, H Rizavi, EH Cook… - PloS one, 2014 - journals.plos.org
Because of the role played by miRNAs in post-transcriptional regulation of an array of
genes, their impact in neuropsychiatric disease pathophysiology has increasingly been …
genes, their impact in neuropsychiatric disease pathophysiology has increasingly been …
Synaptic elimination in neurological disorders
PL Cardozo, I de Lima, E Maciel… - Current …, 2019 - ingentaconnect.com
Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …