[HTML][HTML] Metformin-NSAIDs molecular salts: A path towards enhanced oral bioavailability and stability

FJ Acebedo-Martínez, A Domínguez-Martín… - Pharmaceutics, 2023 - mdpi.com
According to the World Health Organization, more than 422 million people worldwide have
diabetes. The most common oral treatment for type 2 diabetes is the drug metformin (MTF) …

Exploring the differences in crystal structure landscapes and physicochemical properties of enrofloxacin through the number of-OH in coformers: A case study

Q An, L Liu, Y Li, J Shi, Y Zhang, Y Liu, H Zhang… - Journal of Molecular …, 2024 - Elsevier
In the present work, the effect of the number of hydroxyl groups in the hydroxybenzoic acid
on the cocrystallization of enrofloxacin, including the conformation of enrofloxacin in the …

[HTML][HTML] Enhanced NSAIDs Solubility in Drug–Drug Formulations with Ciprofloxacin

FJ Acebedo-Martínez, A Domínguez-Martín… - International Journal of …, 2023 - mdpi.com
Drug–drug salts are a kind of pharmaceutical multicomponent solid in which the two co-
existing components are active pharmaceutical ingredients (APIs) in their ionized forms. This …

Drug-drug salts of Naftopidil with non-steroidal anti-inflammatory drugs for potential multi-drug therapy

RK Bandaru, L Giri, P Kesharwani… - Colloids and Surfaces A …, 2024 - Elsevier
Drug-drug cocrystals (DDCs) are a subclass of pharmaceutical cocrystals in which both the
components of a cocrystal are active drugs. DDCs are the recent advancement based on the …

Novel drug-drug salt crystals of metformin with ibuprofen or naproxen: Improved solubility, dissolution rate, and synergistic antinociceptive effects

HM Qin, ZK Luo, HL Zhou, J Zhu, XY Xiao… - International Journal of …, 2024 - Elsevier
As the monotherapy of available analgesics is usually accompanied by serious side effects
or limited efficacy in the management of chronic pain, multimodal analgesia is widely used …

A new avibactam Gemini quaternary ammonium salt: synthesis, self-assembly, vibrational spectra, crystal structures and DFT calculations

S Wang, X Zhao, H Chang, Z Chen, R Qiao… - Journal of Molecular …, 2023 - Elsevier
Abstract Avibactam ([AV]), a non-β-lactam β-lactamase inhibitor, contains a sulfonic acid
group, which making separation and purification extremely difficult. The ability of the gemini …

A Novel Drug‐Drug Salt of Naproxen and Vortioxetine: Synthesis, Characterization, and Solubility Study

X Zhang, Y Gao - Journal of Chemistry, 2023 - Wiley Online Library
Naproxen (NAP) is an aromatic propionic acid nonsteroidal anti‐inflammatory drug, and
vortioxetine (VOT) is a novel antidepressant drug. In this study, a new 1: 1 drug‐drug salt of …

Analysis of Tolfenamic Acid using a Simple, Rapid, and Stability-indicating Validated HPLC Method

SH Kazi, MA Sheraz, SG Musharraf… - Anti-Inflammatory & …, 2024 - ingentaconnect.com
Background: Tolfenamic acid (TA) belongs to the fenamates class of nonsteroidal anti-
inflammatory drugs. Insufficient information is available regarding the availability of a …