Although modern techniques such as two-photon microscopy can now provide cellular-level
three-dimensional imaging of the intact living brain, the speed and fields of view of these …

Optical approaches to investigate cerebral function and metabolism have long been applied
in invasive studies. From the neuron cultured in vitro to the exposed cortex in the human …

Brain hemodynamics serve as a proxy for neural activity in a range of noninvasive
neuroimaging techniques including functional magnetic resonance imaging (fMRI). In …

Near infrared spectroscopy (NIRS) is a promising technology for functional brain imaging
which measures hemodynamic signals from the cortex, similar to functional magnetic …

Imaging techniques based on optical contrast analysis can be used to visualize dynamic
and functional properties of the nervous system via optical signals resulting from changes in …

Near-infrared spectroscopy (NIRS) has been used to noninvasively monitor adult human
brain function in a wide variety of tasks. While rough spatial correspondences with maps …

Near-infrared spectroscopy (NIRS) and diffuse optical imaging (DOI) are finding widespread
application in the study of human brain activation, motivating further application-specific …

We investigated slow spontaneous oscillations in cerebral oxygenation in the human adult's
visual cortex. The rationale was (1) to demonstrate their detectability by near infrared …

Near infrared spectroscopy (NIRS) can detect changes in the concentrations of oxy-
hemoglobin ([HbO]) and deoxy-hemoglobin ([Hb]) in tissue based upon differential …

Diffuse optical tomography (DOT) is an attractive approach for evaluating stroke physiology.
It provides hemodynamic and metabolic imaging with unique potential for continuous …