The DAP pathway to lysine as a target for antimicrobial agents
RJ Cox - Natural product reports, 1996 - pubs.rsc.org
The enzymes which catalyse the synthesis of L-lysine in plants and bacteria have
attracted'interest from two directions; firstly from those interested in inhibiting lysine …
attracted'interest from two directions; firstly from those interested in inhibiting lysine …
Computing the shortest elementary flux modes in genome-scale metabolic networks
Abstract Motivation: Elementary flux modes (EFMs) represent a key concept to analyze
metabolic networks from a pathway-oriented perspective. In spite of considerable work in …
metabolic networks from a pathway-oriented perspective. In spite of considerable work in …
Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose: roles of malic enzyme and fructose-1, 6-bisphosphatase
T Georgi, D Rittmann, VF Wendisch - Metabolic engineering, 2005 - Elsevier
In the biotechnological production of l-lysine and l-glutamate by Corynebacterium
glutamicum media based on glucose, fructose or sucrose are typically used. Glutamate …
glutamicum media based on glucose, fructose or sucrose are typically used. Glutamate …
The fruits of molecular physiology: engineering the L-isoleucine biosynthesis pathway in Corynebacterium glutamicum
L Eggeling, S Morbach, H Sahm - Journal of biotechnology, 1997 - Elsevier
The known processes for microbial l-isoleucine production include:(i) the conversion of
precursors;(ii) the use of classically derived strains to overcome the regulation within …
precursors;(ii) the use of classically derived strains to overcome the regulation within …
Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves l-lysine formation
A Kabus, T Georgi, VF Wendisch, M Bott - Applied microbiology and …, 2007 - Springer
A critical factor in the biotechnological production of l-lysine with Corynebacterium
glutamicum is the sufficient supply of NADPH. The membrane-integral nicotinamide …
glutamicum is the sufficient supply of NADPH. The membrane-integral nicotinamide …
Co-expression of feedback-resistant threonine dehydratase and acetohydroxy acid synthase increase L-isoleucine production in Corynebacterium glutamicum
L Yin, X Hu, D Xu, J Ning, J Chen, X Wang - Metabolic engineering, 2012 - Elsevier
Threonine dehydratase and acetohydroxy acid synthase are critical enzymes in the l-
isoleucine biosynthesis pathway of Corynebacterium glutamicum, but their activities are …
isoleucine biosynthesis pathway of Corynebacterium glutamicum, but their activities are …
Modeling and experimental design for metabolic flux analysis of lysine-producing Corynebacteria by mass spectrometry
C Wittmann, E Heinzle - Metabolic engineering, 2001 - Elsevier
Experimental design of 13C-tracer studies for metabolic flux analysis with mass
spectrometric determination of labeling patterns was performed for the central metabolism of …
spectrometric determination of labeling patterns was performed for the central metabolism of …
Improved L-lysine yield with Corynebacterium glutamicum: use of dapA resulting in increased flux combined with growth limitation
L Eggeling, S Oberle, H Sahm - Applied microbiology and biotechnology, 1998 - Springer
The amino acid L-lysine is produced on a large scale using mutants of Corynebacterium
glutamicum. However, as yet recombinant DNA techniques have not succeed in improving …
glutamicum. However, as yet recombinant DNA techniques have not succeed in improving …
Application of MALDI‐TOF MS to lysine‐producing Corynebacterium glutamicum A novel approach for metabolic flux analysis
C Wittmann, E Heinzle - European journal of biochemistry, 2001 - Wiley Online Library
In the present work, a novel comprehensive approach of 13C‐tracer studies with labeling
measurements by MALDI‐TOF MS, and metabolite balancing was developed to elucidate …
measurements by MALDI‐TOF MS, and metabolite balancing was developed to elucidate …
[PDF][PDF] The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute …
M Vrljic, J Garg, A Bellmann, S Wachi… - Journal of molecular …, 1999 - caister.com
Abstract In Corynebacterium glutamicum the LysE carrier protein exhibits the unique
function of exporting L-lysine. We here analyze the membrane topology of LysE, a protein of …
function of exporting L-lysine. We here analyze the membrane topology of LysE, a protein of …