Molecular imaging in drug development

JK Willmann, N Van Bruggen, LM Dinkelborg… - Nature reviews Drug …, 2008 - nature.com
Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …

[HTML][HTML] Imaging-based tumor treatment response evaluation: review of conventional, new, and emerging concepts

H Kang, HY Lee, KS Lee, JH Kim - Korean journal of radiology, 2012 - ncbi.nlm.nih.gov
Tumor response may be assessed readily by the use of Response Evaluation Criteria in
Solid Tumor version 1.1. However, the criteria mainly depend on tumor size changes. These …

Tumor volume combined with number of positive lymph node stations is a more important prognostic factor than TNM stage for survival of non–small-cell lung cancer …

C Dehing-Oberije, D De Ruysscher… - International Journal of …, 2008 - Elsevier
PURPOSE: The current tumor, node, metastasis system needs refinement to improve its
ability to predict survival of patients with non–small-cell lung cancer (NSCLC) treated with …

Is 18F-FDG PET/CT useful for the early prediction of histopathologic response to neoadjuvant erlotinib in patients with non–small cell lung cancer?

TS Aukema, I Kappers, RAV Olmos… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Early prediction of treatment response is of value in avoiding the unnecessary toxicity of
ineffective treatment. The objective of this study was to prospectively evaluate the role of …

18F-FDG PET for the lymph node staging of non-small cell lung cancer in a tuberculosis-endemic country: Is dual time point imaging worth the effort?

RF Yen, KC Chen, JM Lee, YC Chang, J Wang… - European journal of …, 2008 - Springer
Purpose This study was to compare 18 F-FDG positron emission tomography (PET) with
thoracic contrast-enhanced CT (CECT) in the ability of lymph node (LN) staging non-small …

[HTML][HTML] Randomised phase 3 study of adjuvant chemotherapy with or without nadroparin in patients with completely resected non-small-cell lung cancer: the NVALT …

HJM Groen, EHFM van der Heijden… - British journal of …, 2019 - nature.com
Background Retrospective studies suggest that low molecular weight heparin may delay the
development of metastasis in patients with resected NSCLC. Methods Multicentre phase 3 …

18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases

VM Petriev, VK Tishchenko, RN Krasikova - Pharmaceutical Chemistry …, 2016 - Springer
This review addresses progress in the radionuclide diagnosis of oncological diseases using
radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most …

全身PET/CT 在非小细胞肺癌预后判断中的价值

肖鑫武, 宋勇, 朱虹, 冯根宝, 胡裕效, 施毅, 徐小勇 - 医学研究生学报, 2010 - cqvip.com
目的PET/CT (integrated positron emission tomography/computerized tomography)
对肺癌的诊断及分期价值已得到广泛的认同, 但其对肺癌预后及疗效评估的价值还存在争议 …

FDG-PET/CT in lung cancer: an update

RP Baum, C Świętaszczyk, V Prasad - … in the Treatment of Lung Cancer, 2010 - karger.com
The prognosis of lung cancer patients mostly depends on the stage at which the disease is
diagnosed. Contrast-enhanced CT (ceCT) and MRI play a significant role in initial staging …

T1 期肺癌原发灶^ 18F—FDG 摄取与转移的关系

李明焕, 胡漫, 张品良, 孔莉, 刘宁波, 于金明 - 中华核医学杂志, 2008 - cqvip.com
目的探讨T1 期肺癌原发灶^ 18F-脱氧葡萄糖(FDG) 摄取与病灶大小, 淋巴结转移, 远处转移,
病理类型的关系. 方法对61 例治疗前行全身” F—FDGPET/CT 扫描的T1 期肺癌患者 …