Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease

B Thompson, EA Davidson, W Liu, DW Nebert… - Human genetics, 2021 - Springer
Paired-box (PAX) genes encode a family of highly conserved transcription factors found in
vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain …

Pitx genes in development and disease

TQ Tran, C Kioussi - Cellular and Molecular Life Sciences, 2021 - Springer
Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize
specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential …

The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains

NJ Strausfeld, X Hou, ME Sayre, F Hirth - Science, 2022 - science.org
For more than a century, the origin and evolution of the arthropod head and brain have
eluded a unifying rationale reconciling divergent morphologies and phylogenetic …

[HTML][HTML] A Toll-receptor map underlies structural brain plasticity

G Li, MG Forero, JS Wentzell, I Durmus, R Wolf… - Elife, 2020 - elifesciences.org
Experience alters brain structure, but the underlying mechanism remained unknown.
Structural plasticity reveals that brain function is encoded in generative changes to cells that …

[HTML][HTML] An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis

DJ Leite, A Schönauer, G Blakeley, A Harper… - EvoDevo, 2024 - Springer
Spiders are a diverse order of chelicerates that diverged from other arthropods over 500
million years ago. Research on spider embryogenesis, particularly studies using the …

The fly eye: Through the looking glass

JP Kumar - Developmental dynamics, 2018 - Wiley Online Library
The developing eye‐antennal disc of Drosophila melanogaster has been studied for more
than a century, and it has been used as a model system to study diverse processes, such as …

Micro-computed tomography as a platform for exploring Drosophila development

TA Schoborg, SL Smith, LN Smith, HD Morris… - …, 2019 - journals.biologists.com
Understanding how events at the molecular and cellular scales contribute to tissue form and
function is key to uncovering the mechanisms driving animal development, physiology and …

[HTML][HTML] Protocol to study cell death using TUNEL assay in Drosophila imaginal discs

AV Chimata, P Deshpande, AS Mehta, A Singh - STAR protocols, 2022 - Elsevier
Cell death maintains tissue homeostasis by eliminating dispensable cells. Misregulation of
cell death is seen in diseases like cancer, neurodegeneration, etc. Therefore, cell death …

[HTML][HTML] Altering the temporal regulation of one transcription factor drives evolutionary trade-offs between head sensory organs

A Ramaekers, A Claeys, M Kapun, E Mouchel-Vielh… - Developmental cell, 2019 - cell.com
Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution.
This could result from genetic or functional constraints. We demonstrate that head sensory …

[HTML][HTML] Notch signaling in insect development: A simple pathway with diverse functions

Y Chen, H Li, TC Yi, J Shen, J Zhang - International Journal of Molecular …, 2023 - mdpi.com
Notch signaling is an evolutionarily conserved pathway which functions between adjacent
cells to establish their distinct identities. Despite operating in a simple mechanism, Notch …