Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease
Paired-box (PAX) genes encode a family of highly conserved transcription factors found in
vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain …
vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain …
Pitx genes in development and disease
Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize
specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential …
specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential …
The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains
For more than a century, the origin and evolution of the arthropod head and brain have
eluded a unifying rationale reconciling divergent morphologies and phylogenetic …
eluded a unifying rationale reconciling divergent morphologies and phylogenetic …
[HTML][HTML] A Toll-receptor map underlies structural brain plasticity
Experience alters brain structure, but the underlying mechanism remained unknown.
Structural plasticity reveals that brain function is encoded in generative changes to cells that …
Structural plasticity reveals that brain function is encoded in generative changes to cells that …
[HTML][HTML] An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis
DJ Leite, A Schönauer, G Blakeley, A Harper… - EvoDevo, 2024 - Springer
Spiders are a diverse order of chelicerates that diverged from other arthropods over 500
million years ago. Research on spider embryogenesis, particularly studies using the …
million years ago. Research on spider embryogenesis, particularly studies using the …
The fly eye: Through the looking glass
JP Kumar - Developmental dynamics, 2018 - Wiley Online Library
The developing eye‐antennal disc of Drosophila melanogaster has been studied for more
than a century, and it has been used as a model system to study diverse processes, such as …
than a century, and it has been used as a model system to study diverse processes, such as …
Micro-computed tomography as a platform for exploring Drosophila development
TA Schoborg, SL Smith, LN Smith, HD Morris… - …, 2019 - journals.biologists.com
Understanding how events at the molecular and cellular scales contribute to tissue form and
function is key to uncovering the mechanisms driving animal development, physiology and …
function is key to uncovering the mechanisms driving animal development, physiology and …
[HTML][HTML] Protocol to study cell death using TUNEL assay in Drosophila imaginal discs
Cell death maintains tissue homeostasis by eliminating dispensable cells. Misregulation of
cell death is seen in diseases like cancer, neurodegeneration, etc. Therefore, cell death …
cell death is seen in diseases like cancer, neurodegeneration, etc. Therefore, cell death …
[HTML][HTML] Altering the temporal regulation of one transcription factor drives evolutionary trade-offs between head sensory organs
A Ramaekers, A Claeys, M Kapun, E Mouchel-Vielh… - Developmental cell, 2019 - cell.com
Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution.
This could result from genetic or functional constraints. We demonstrate that head sensory …
This could result from genetic or functional constraints. We demonstrate that head sensory …
[HTML][HTML] Notch signaling in insect development: A simple pathway with diverse functions
Y Chen, H Li, TC Yi, J Shen, J Zhang - International Journal of Molecular …, 2023 - mdpi.com
Notch signaling is an evolutionarily conserved pathway which functions between adjacent
cells to establish their distinct identities. Despite operating in a simple mechanism, Notch …
cells to establish their distinct identities. Despite operating in a simple mechanism, Notch …