Abstract C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily
affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G …

Among the broad spectrum of membranoproliferative glomerulonephritis (MPGN),
immunofluorescence distinguishes C3 glomerulopathy (C3G), with predominant C3 …

Rationale & Objective C3 glomerulopathy (C3GN) and atypical hemolytic uremic syndrome
(aHUS) are 2 distinct rare kidney diseases caused by dysregulation of the alternative …

Uncontrolled complement activation can cause or contribute to glomerular injury in multiple
kidney diseases. While complement activation plays a causal role in atypical hemolytic …

Recent advances in the treatment of plasma cell disorders (PCDs) have provided a wealth of
therapy alternatives and improved overall survival tremendously. Various types of PCDs are …

The complement system is part of innate immunity and is pivotal in protecting the body
against pathogens and maintaining host homeostasis. Activation of the complement system …

Background C3 glomerulopathy is a rare and heterogeneous complement-driven disease. It
is often challenging to accurately predict in clinical practice the individual kidney prognosis …

Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are types of
membranoproliferative glomerulonephritis classified as C3 glomerulopathies. These …

Purpose Anti-complement factor H (CFH) autoantibodies could be detected in lupus and its
significance remained to be elucidated. Herein, we aimed to explore the roles of anti-CFH …

Although rare, C3 glomerulopathy (C3G) is increasingly recognized thanks to the currently
available diagnostic skills. C3G is not a single disease but a group of disorders with distinct …