A previous linkage study provided evidence for a prostate cancer–susceptibility locus at
1q24-25. Subsequent reports in additional collections of families have yielded conflicting …

Approximately 5–10% of prostate cancer cases are caused by dominantly inherited
susceptibility to the disease. Although advances have been made in research concerning …

Objectives Prostate cancer is a prevalent disease with a high impact on patients' morbidity
and mortality. Despite efforts to profile prostate cancer, the genetic alterations and biological …

As with many complex genetic diseases, genome scans for prostate cancer have given
conflicting results, often failing to provide replication of previous findings. One factor …

Prostate cancer is one of the most common cancers among men and has long been
recognized to occur in familial clusters. Brothers and sons of affected men have a 2–3-fold …

Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

A systematic analysis of cancer risks to offspring and to siblings of cancer cases was carried
out based on the nation-wide Swedish Family-Cancer Database. For all 13 cancer sites …

During embryonic development, one of the two X chromosomes of a mammalian female cell
is randomly inactivated by the X chromosome inactivation mechanism, which is mainly …

The aggressiveness of prostate cancer (PCa) varies widely: some tumors progress to
invasive, potentially life-threatening disease, whereas others stay latent for the remainder of …

The molecular mechanisms underlying the development and progression of prostate cancer
are poorly understood. Epidemiological studies have suggested that 5-10% of all prostate …