The neuroimmune CGRP–RAMP1 axis tunes cutaneous adaptive immunity to the microbiota
W Kulalert, AC Wells, VM Link, AI Lim… - Proceedings of the …, 2024 - National Acad Sciences
The somatosensory nervous system surveils external stimuli at barrier tissues, regulating
innate immune cells under infection and inflammation. The roles of sensory neurons in …
innate immune cells under infection and inflammation. The roles of sensory neurons in …
[HTML][HTML] Glutamate in primary afferents is required for itch transmission
Whether glutamate or itch-selective neurotransmitters are used to confer itch specificity is
still under debate. We focused on an itch-selective population of primary afferents …
still under debate. We focused on an itch-selective population of primary afferents …
[HTML][HTML] Molecular identity of proprioceptor subtypes innervating different muscle groups in mice
The precise execution of coordinated movements depends on proprioception, the sense of
body position in space. However, the molecular underpinnings of proprioceptive neuron …
body position in space. However, the molecular underpinnings of proprioceptive neuron …
Variation is function: Are single cell differences functionally important? Testing the hypothesis that single cell variation is required for aggregate function
H Dueck, J Eberwine, J Kim - BioEssays, 2016 - Wiley Online Library
There is a growing appreciation of the extent of transcriptome variation across individual
cells of the same cell type. While expression variation may be a byproduct of, for example …
cells of the same cell type. While expression variation may be a byproduct of, for example …
RNA-Seq investigations of human post-mortem trigeminal ganglia
DM LaPaglia, MR Sapio, PD Burbelo… - …, 2018 - journals.sagepub.com
Background The trigeminal ganglion contains neurons that relay sensations of pain, touch,
pressure, and many other somatosensory modalities to the central nervous system. The …
pressure, and many other somatosensory modalities to the central nervous system. The …
[HTML][HTML] Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic pain that
severely affects quality of life. Although the underlying pathophysiology is not well …
severely affects quality of life. Although the underlying pathophysiology is not well …
[HTML][HTML] Neurons and microglia; a sickly-sweet duo in diabetic pain neuropathy
T Rajchgot, SC Thomas, JC Wang, M Ahmadi… - Frontiers in …, 2019 - frontiersin.org
Diabetes is a common condition characterized by persistent hyperglycemia. High blood
sugar primarily affects cells that have a limited capacity to regulate their glucose intake …
sugar primarily affects cells that have a limited capacity to regulate their glucose intake …
[HTML][HTML] Peripheral mechanisms of chronic pain
Acutely, pain serves to protect us from potentially harmful stimuli, however damage to the
somatosensory system can cause maladaptive changes in neurons leading to chronic pain …
somatosensory system can cause maladaptive changes in neurons leading to chronic pain …
[HTML][HTML] Pruritus: a sensory symptom generated in cutaneous immuno-neuronal crosstalk
Pruritus or itch generated in the skin is one of the most widespread symptoms associated
with various dermatological and systemic (immunological) conditions. Although many details …
with various dermatological and systemic (immunological) conditions. Although many details …
IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis
Objective To investigate the role of IL-33 in gouty arthritis. Material 174 Balb/c (wild-type)
and 54 ST2−/− mice were used in this study. In vitro experiments were conducted in bone …
and 54 ST2−/− mice were used in this study. In vitro experiments were conducted in bone …