The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …

Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …

Cell death in neurodegenerative diseases is often thought to be governed by apoptosis;
however, an increasing body of evidence suggests the involvement of alternative cell death …

Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become
established as a key modulator of gene expression regulating numerous aspects of cell …

Niemann-Pick type C (NPC) disease is a lysosomal storage disease in which endocytosed
cholesterol becomes sequestered in late endosomes/lysosomes (LEs/Ls) because of …

Brain aging is linked to certain types of neurodegenerative diseases and identifying new
therapeutic targets has become critical. Melatonin, a pineal hormone, associates with …

Modulation of gene expression is a constant and necessary event for mammalian brain
function. An important way of regulating gene expression is through the remodeling of …

Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Many populations worldwide are suffering from central nervous system (CNS) diseases such
as brain tumors, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease …