Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …

Recent advances in the pathophysiologic understanding of coronavirus disease 2019
(COVID-19) suggests that cytokine release syndrome (CRS) has an association with the …

Chronic wounds arise from interruption of normal healing due to many potential
pathophysiological factors. Monitoring these multivariate factors can provide personalized …

Rationale: Dysregulation of arachidonic acid (ARA) metabolism results in inflammation;
however, its role in acute lung injury (ALI) remains elusive. In this study, we addressed the …

Introduction The cytokine release syndrome (CRS) of COVID-19 is associated with the
development of critical illness requiring multi-organ support. Further research is required to …

Aims The management of acute liver failure (ALF) is a major challenge worldwide. The
current study aimed to determine the therapeutic potential of TNF-α pretreatment of umbilical …

Rheumatoid arthritis (RA), a chronic autoimmune disease (AD), can cause irreversible loss
of joint function. The methotrexate (MTX) is the first-line choice in the treatment of RA; …

Programmed death ligand 1 (PD-L1) is not only an important molecule in mediating tumor
immune escape, but also regulates inflammation development. Here we showed that PD-L1 …

Gene therapy is a promising novel method of tissue regeneration by stimulating or inhibiting
key signaling pathways. However, their therapeutic applications in vivo are largely limited by …