Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …

Background Terminally ill patients may experience existential distress, depression, or
anxiety, limiting quality of life in the final stage. Existing psychotherapeutic or …

Importance Although classic psychedelic medications have shown promise in the treatment
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …

Survey-based studies suggest naturalistic psychedelic use provides mental health benefits
similar to those observed in clinical trials. The current study sought to confirm these findings …

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

Background: Despite the growth of psychedelic research, psychedelic-assisted group
psychotherapy (PAGP) has received little attention in comparison to individual psychedelic …

Ketamine is a dissociative drug that has been used medically since the 1970s primarily as
an anesthetic agent but also for various psychiatric applications. Anecdotal reports and …

Recent research has demonstrated the potential of psychedelic therapy for mental health
care. However, the psychological experience underlying its therapeutic effects remains …

Introduction Psychedelic drugs were used quite extensively before their prohibition in 1968
which delayed research. However, since the 1990s, studies on the potential therapeutic …

Background Outcomes of ketamine intravenous therapy (KIT) for depression in real-world
care settings have been minimally evaluated. We set out to quantify treatment response to …