[HTML][HTML] Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases

G Li, T Chen, J Dahlman… - Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) carry diverse bioactive components including nucleic acids,
proteins, lipids and metabolites that play versatile roles in intercellular and interorgan …

[HTML][HTML] Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

JC Contreras-Naranjo, HJ Wu, VM Ugaz - Lab on a Chip, 2017 - pubs.rsc.org
Exosomes, the smallest sized extracellular vesicles (∽ 30–150 nm) packaged with lipids,
proteins, functional messenger RNAs and microRNAs, and double-stranded DNA from their …

Extracellular vesicles in angiogenesis

D Todorova, S Simoncini, R Lacroix, F Sabatier… - Circulation …, 2017 - Am Heart Assoc
During the past decade, extracellular vesicles (EVs), which include apoptotic bodies,
microvesicles, and exosomes, have emerged as important players in cell-to-cell …

Comparison of small extracellular vesicles isolated from plasma by ultracentrifugation or size-exclusion chromatography: yield, purity and functional potential

K Takov, DM Yellon, SM Davidson - Journal of extracellular …, 2019 - Taylor & Francis
Interest in small extracellular vesicles (sEVs) as functional carriers of proteins and nucleic
acids is growing continuously. There are large numbers of sEVs in the blood, but lack of …

[HTML][HTML] A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents

I Helwa, J Cai, MD Drewry, A Zimmerman, MB Dinkins… - PloS one, 2017 - journals.plos.org
Exosomes play a role in cell-to-cell signaling and serve as possible biomarkers. Isolating
exosomes with reliable quality and substantial concentration is a major challenge. Our …

MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment

WS Toh, RC Lai, JHP Hui, SK Lim - Seminars in cell & developmental …, 2017 - Elsevier
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …

[HTML][HTML] Neutrophils in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus: same foe different MO

M Fresneda Alarcon, Z McLaren, HL Wright - Frontiers in immunology, 2021 - frontiersin.org
Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Extracellular vesicles and their emerging roles as cellular messengers in endocrinology: an endocrine society scientific statement

C Salomon, S Das, U Erdbrügger, R Kalluri… - Endocrine …, 2022 - academic.oup.com
During the last decade, there has been great interest in elucidating the biological role of
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …

JPG Sluijter, SM Davidson, CM Boulanger… - Cardiovascular …, 2018 - academic.oup.com
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …