Epidemiological and clinical data indicate high comorbidity between depression and drug
dependence that may reflect an attempt to self-medicate with drugs of abuse. The present …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Background: Neuropeptide-Y (NPY) is present in extensive neuronal systems of the brain
and is present in high concentrations in cell bodies and terminals in the amygdala …

The Flinders Sensitive Line (FSL) rats were originally selectively bred for increased
responses to an anticholinesterase agent. The FSL rat partially resembles depressed …

Exposure to severe stress leads to development of neuropsychiatric disorders, including
depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide …

Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian
nervous system and exhibits a diverse range of important physiological activities, including …

The amygdala complex integrates stressful stimuli and is critical in transducing their aversive
value into autonomic, endocrine and behavioural responses. Stimulation within the …

The function of neuropeptide Y, one of the most abundant peptide transmitters of the
mammalian brain, remains unclear because of a lack of specific receptor antagonists. An …

Background: Consistent with many studies demonstrating enhanced reactivity of the
sympathetic nervous system in posttraumatic stress disorder (PTSD), the administration of …

Neuropeptide Y (NPY) is one of the most abundant peptides in the central nervous system
and currently there are four known receptor subtypes Y1, Y2, Y4 and Y5. Central NPY and …