Animal models, particularly mouse models, play a central role in the study of the etiology,
prevention, and treatment of human prostate cancer. While tissue culture models are …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Effective clinical management of prostate cancer (PCA) has been challenged by significant
intratumoural heterogeneity on the genomic and pathological levels and limited …

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases …

Abstract When the National Institutes of Health Mouse Models of Human Cancer Consortium
initiated the Prostate Steering Committee 15 years ago, there were no genetically …

The development and optimization of high‐throughput screening methods has identified a
multitude of genetic changes associated with human disease. The use of immunodeficient …

Genetically engineered mouse models (GEMMs) of human cancer were first created nearly
30 years ago. These early transgenic models demonstrated that mouse cells could be …

Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of
cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; …

The complex dynamics of the tumor microenvironment and prostate cancer heterogeneity
have confounded efforts to establish suitable preclinical mouse models to represent human …

The ATBF1/ZFHX3 gene at 16q22 is the second most frequently mutated gene in human
prostate cancer and has reduced expression or mislocalization in several types of human …