TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Emerging pharmaceutical therapies for osteoarthritis
A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …
steadily increasing worldwide, representing a major public health challenge for the coming …
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …
conditionally conduct small and large cations. Such functional plasticity is presumably …
[HTML][HTML] TRP channels in thermosensation
M Kashio, M Tominaga - Current Opinion in Neurobiology, 2022 - Elsevier
The ability to sense external temperature is assumed by somatosensory neurons, in which
temperature information is converted to neural activity by afferent input to the central nervous …
temperature information is converted to neural activity by afferent input to the central nervous …
[HTML][HTML] Regulation of body temperature by the nervous system
The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …
system. Here we review our current understanding of thermoregulation in mammals. We …
Central mechanisms for thermoregulation
SF Morrison, K Nakamura - Annual review of physiology, 2019 - annualreviews.org
Maintenance of a homeostatic body core temperature is a critical brain function
accomplished by a central neural network. This orchestrates a complex behavioral and …
accomplished by a central neural network. This orchestrates a complex behavioral and …
Neuronal regulation of immunity: why, how and where?
M Schiller, TL Ben-Shaanan, A Rolls - Nature Reviews Immunology, 2021 - nature.com
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …
reason; it fills the gap between two principal systems of the organism, the nervous system …
[HTML][HTML] An atlas of vagal sensory neurons and their molecular specialization
Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …
TFOS DEWS II pain and sensation report
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …
Flexible optoelectronic multimodal proximity/pressure/temperature sensors with low signal interference
Multimodal tactile sensors are a crucial part of intelligent human‐machine interaction and
collaboration. Simultaneous detection of proximity, pressure, and temperature on a single …
collaboration. Simultaneous detection of proximity, pressure, and temperature on a single …