TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Emerging pharmaceutical therapies for osteoarthritis

A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

K Zhang, D Julius, Y Cheng - Cell, 2021 - cell.com
Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …

[HTML][HTML] TRP channels in thermosensation

M Kashio, M Tominaga - Current Opinion in Neurobiology, 2022 - Elsevier
The ability to sense external temperature is assumed by somatosensory neurons, in which
temperature information is converted to neural activity by afferent input to the central nervous …

[HTML][HTML] Regulation of body temperature by the nervous system

CL Tan, ZA Knight - Neuron, 2018 - cell.com
The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …

Central mechanisms for thermoregulation

SF Morrison, K Nakamura - Annual review of physiology, 2019 - annualreviews.org
Maintenance of a homeostatic body core temperature is a critical brain function
accomplished by a central neural network. This orchestrates a complex behavioral and …

Neuronal regulation of immunity: why, how and where?

M Schiller, TL Ben-Shaanan, A Rolls - Nature Reviews Immunology, 2021 - nature.com
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …

[HTML][HTML] An atlas of vagal sensory neurons and their molecular specialization

J Kupari, M Häring, E Agirre, G Castelo-Branco… - Cell reports, 2019 - cell.com
Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …

TFOS DEWS II pain and sensation report

C Belmonte, JJ Nichols, SM Cox, JA Brock, CG Begley… - The ocular …, 2017 - Elsevier
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Flexible optoelectronic multimodal proximity/pressure/temperature sensors with low signal interference

S Wang, X Wang, Q Wang, S Ma, J Xiao… - Advanced …, 2023 - Wiley Online Library
Multimodal tactile sensors are a crucial part of intelligent human‐machine interaction and
collaboration. Simultaneous detection of proximity, pressure, and temperature on a single …