Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It
lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ 9 …

The sensation of pain alerts us to real or impending injury and triggers appropriate
protective responses. Unfortunately, pain often outlives its usefulness as a warning system …

The variety of taste sensations, including sweet, umami, bitter, sour, and salty, arises from
diverse taste cells, each of which expresses specific taste sensor molecules and associated …

Recently, optical stimulation,, has begun to unravel the neuronal processing that controls
certain animal behaviours,. However, optical approaches are limited by the inability of …

A distinct subset of sensory neurons are thought to directly sense changes in thermal energy
through their termini in the skin. Very little is known about the molecules that mediate …

Central neural circuits orchestrate a homeostatic repertoire to maintain body temperature
during environmental temperature challenges and to alter body temperature during the …

Body temperature regulation is a fundamental homeostatic function that is governed by the
central nervous system in homeothermic animals, including humans. The central …

Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …

Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds.
Topical application of mustard oil (allyl isothiocyanate) to the skin activates underlying …

Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable
nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 …