In this review, we focus on significant developments in our understanding of the
mechanisms that control the cutaneous vasculature in humans, with emphasis on the …

The transient receptor potential (TRP) protein superfamily consists of a diverse group of
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …

The mammalian sensory system is capable of discriminating thermal stimuli ranging from
noxious cold to noxious heat. Principal temperature sensors belong to the TRP cation …

Ca 2+-permeable channels that are involved in the responses of mammalian cells to
changes in extracellular osmolarity have not been characterized at the molecular level. Here …

We possess an acute sense of temperature. Most of us seek shade on a hot summer day,
prefer a warm shower to a cold one, and enjoy red wines served at a temperature of 15–18° …

We describe a paradigm for nociception in Drosophila. In response to the touch of a probe
heated above 38° C, Drosophila larvae produce a stereotypical rolling behavior, unlike the …

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with
functions widely linked to the generation of pain. Several agonists of exogenous and …

Transient receptor potential (TRP) proteins are cation-selective channels that function in
processes as diverse as sensation and vasoregulation. Mammalian TRP channels that are …

The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also
known as VR1) antagonists is based on the concept that endogenous agonists acting on …

Tissue injury generates endogenous factors that heighten our sense of pain by increasing
the response of sensory nerve endings to noxious stimuli,. Bradykinin and nerve growth …