Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …

Abstract Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive,
nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and …

The transient receptor potential (TRP) superfamily of cation channels contains four
temperature‐sensitive channels, named TRPV1–4, that are activated by heat stimuli from …

The design of antisense oligonucleotides containing locked nucleic acids (LNA) was
optimized and compared to intensively studied DNA oligonucleotides, phosphorothioates …

TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent
somatosensory neurons that contain substance P and calcitonin gene-related peptide …

Although skeletal pain plays a major role in reducing the quality of life in patients suffering
from osteoarthritis, Paget's disease, sickle cell anemia and bone cancer, little is known about …

The sensation of pressure, mechanosensation, in vertebrates remains poorly understood on
the molecular level. The ion channel TRPV4 is in the TRP family and is a candidate for a …

We have compared activation by heat of TRPV4 channels, heterogeneously expressed in
HEK293 cells, and endogenous channels in mouse aorta endothelium (MAEC). Increasing …

Capsaicin, a pungent ingredient of hot peppers, causes excitation of small sensory neurons,
and thereby produces severe pain. A nonselective cation channel activated by capsaicin …

The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …