The cloned vanilloid receptor VR1 has attracted recent attention as a molecular integrator of
painful stimuli on primary sensory neurons. The existence of vanilloid-sensitive neurons in …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Garlic's pungent flavor has made it a popular ingredient in cuisines around the world and
throughout history. Garlic's health benefits have been elevated from folklore to clinical study …

The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion
channels activated by temperature, are expressed in primary sensory nerve terminals where …

The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. The response of …

Optically gated ion channels were expressed in circumscribed groups of neurons in the
Drosophila CNS so that broad illumination of flies evoked action potentials only in …

Pain is necessary for survival, but persistent pain can result in anxiety, depression and a
reduction in the quality of life. The discriminative and affective qualities of pain are both …

Depending on their primary structure, the 28 mammalian transient receptor potential (TRP)
cation channels identified so far can be sorted into 6 subfamilies: TRPC (“Canonical”), TRPV …

Since the initial observations that stimulation of sensory neurons produces vasodilation,
plasma extravasation, and hypersensitivity, much progress has been made in understanding …

The vanilloid receptor (VR1) protein functions both as a receptor for capsaicin and a
transducer of noxious thermal stimuli. To determine the expression and targetting of this …