Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

C Heintz, TK Doktor, A Lanjuin, CC Escoubas, Y Zhang… - Nature, 2017 - nature.com
Ageing is driven by a loss of transcriptional and protein homeostasis,, and is the key risk
factor for multiple chronic diseases. Interventions that attenuate or reverse systemic …

[HTML][HTML] Structural and enzyme kinetic studies of retrograded starch: Inhibition of α-amylase and consequences for intestinal digestion of starch

H Patel, PG Royall, S Gaisford, GR Williams… - Carbohydrate …, 2017 - Elsevier
Retrograded starch is known to be resistant to digestion. We used enzyme kinetic
experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine …

[HTML][HTML] Kombucha Tea-associated microbes remodel host metabolic pathways to suppress lipid accumulation

RN DuMez-Kornegay, LS Baker, AJ Morris… - Plos …, 2024 - journals.plos.org
The popularity of the ancient, probiotic-rich beverage Kombucha Tea (KT) has surged in part
due to its purported health benefits, which include protection against metabolic diseases; …

Olfactory perception of food abundance regulates dietary restriction-mediated longevity via a brain-to-gut signal

B Zhang, H Jun, J Wu, J Liu, XZS Xu - Nature aging, 2021 - nature.com
The role of food nutrients in mediating the positive effect of dietary restriction (DR) on
longevity has been extensively characterized, but how non-nutrient food components …

AMPK‐mediated formation of stress granules is required for dietary restriction‐induced longevity in Caenorhabditis elegans

CT Kuo, GT You, YJ Jian, TS Chen, YC Siao… - Aging …, 2020 - Wiley Online Library
Stress granules (SGs) are nonmembranous organelles that are dynamically assembled and
disassembled in response to various stressors. Under stressed conditions, polyadenylated …

[HTML][HTML] A gene-expression-based neural code for food abundance that modulates lifespan

EV Entchev, DS Patel, M Zhan, AJ Steele, H Lu… - Elife, 2015 - elifesciences.org
How the nervous system internally represents environmental food availability is poorly
understood. Here, we show that quantitative information about food abundance is encoded …

[HTML][HTML] Neuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. elegans

JCS Azevêdo, KC Borges, MI Genovese… - Food Research …, 2015 - Elsevier
The effect of hot air dried camu-camu (Myrciaria dubia HBK McVaugh) residue on
modulating redox response signaling was evaluated in transgenic Caenorhabditis elegans …

[HTML][HTML] The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans

CG Silva-García, LI Láscarez-Lagunas, K Papsdorf… - Nature Aging, 2023 - nature.com
Loss of function during aging is accompanied by transcriptional drift, altering gene
expression and contributing to a variety of age-related diseases. CREB-regulated …

A micro RNA switch controls dietary restriction‐induced longevity through Wnt signaling

Y Xu, Z He, M Song, Y Zhou, Y Shen - EMBO reports, 2019 - embopress.org
Dietary restriction (DR) is known to have a potent and conserved longevity effect, yet its
underlying molecular mechanisms remain elusive. DR modulates signaling pathways in …

[HTML][HTML] BLMP-1 is a critical temporal regulator of dietary-restriction-induced response in Caenorhabditis elegans

Q Hu, Y Xu, M Song, Y Dai, A Antebi, Y Shen - Cell Reports, 2024 - cell.com
The extrinsic diet and the intrinsic developmental programs are intertwined. Although
extensive research has been conducted on how nutrition regulates development, whether …