J. Attems, K. Jellinger, DR Thal and W. Van Nostrand (2011) Neuropathology and Applied
Neurobiology37, 75–93 Sporadic cerebral amyloid angiopathy Cerebral amyloid angiopathy …

Haemoglobin is released into the CNS during the breakdown of red blood cells after
intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin …

Iron is important for brain oxygen transport, electron transfer, neurotransmitter synthesis, and
myelin production. Though iron deposition has been observed in the brain with normal …

Superficial siderosis of the central nervous system results from subpial hemosiderin
deposition due to chronic low‐grade bleeding into the subarachnoid space. The confluent …

In recent years, understanding of the syndromes of neurodegeneration with brain iron
accumulation (NBIA) has grown considerably. In addition to the core syndromes of …

Disturbance of cerebral iron regulation is almost universal in neurodegenerative disorders.
There is a growing body of evidence that increased iron deposits may contribute to …

Central nervous system infratentorial superficial siderosis (iSS) is increasingly detected by
blood‐sensitive magnetic resonance imaging (MRI) sequences. Despite this, there are no …

Our understanding of the syndromes of Neurodegeneration with Brain Iron Accumulation
(NBIA) continues to grow considerably. In addition to the core syndromes of pantothenate …

Chronic or intermittent extravasations of blood into the subarachnoid space, and
dissemination of heme by circulating cerebrospinal fluid, are the only established causes of …

Background and Purpose—Validation of the Boston criteria for the in vivo diagnosis of
cerebral amyloid angiopathy (CAA) is challenging, because noninvasive diagnostic tests do …