Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Rationale: In life-threatening coronavirus disease (COVID-19), corticosteroids reduce
mortality, suggesting that immune responses have a causal role in death. Whether this …

Advancements in methods, technology, and our understanding of the pathobiology of lung
injury have created the need to update the definition of experimental acute lung injury (ALI) …

Background The major sites of obstruction in chronic obstructive pulmonary disease (COPD)
are small airways (< 2 mm in diameter). We wanted to determine whether there was a …

Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension
and involves changes in the intima, media and adventitia, often with the interplay of …

Background The concept that small conducting airways less than 2 mm in diameter become
the major site of airflow obstruction in chronic obstructive pulmonary disease (COPD) is well …

Rationale: The impact of modern treatments of pulmonary arterial hypertension (PAH) on
pulmonary vascular pathology remains unknown. Objectives: To assess the spectrum of …

Thirty years ago, there was an emerging appreciation for the significance of oxidative stress
in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for …

Radiological images have been assessed qualitatively in most clinical settings by the expert
eyes of radiologists and other clinicians. On the other hand, quantification of radiological …