Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Converging evidence from electrophysiological, physiological and anatomical studies
suggests that abnormalities in the synchronized oscillatory activity of neurons may have a …

Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Schizophrenia is a disease of abnormal brain development. Considerable evidence now
indicates that environmental factors have a causative role in schizophrenia. Elevated …

The hippocampus and prefrontal cortex (PFC) have long been known to play a central role
in various behavioral and cognitive functions. More recently, electrophysiological and …

One of the most debilitating aspects of schizophrenia is an apparent interest in or ability to
exert effort for rewards. Such “negative symptoms” may prevent individuals from obtaining …

Increasing epidemiological and experimental evidence implicates gestational infections as
one important factor involved in the pathogenesis of several neuropsychiatric disorders …

Schizophrenia is associated with abnormalities of hippocampal structure and function.
Neuroimaging studies have shown that the hippocampus is hyperactive in schizophrenia …

Substantial evidence suggests that psychosis in schizophrenia is associated with
dysregulation of subcortical dopamine system function. Here we examine evidence that this …