Inhaled corticosteroids in COPD: friend or foe?

A Agusti, LM Fabbri, D Singh, J Vestbo… - European …, 2018 - Eur Respiratory Soc
The efficacy, safety and positioning of inhaled corticosteroids (ICS) in the treatment of
patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can …

Impact and prevention of severe exacerbations of COPD: a review of the evidence

DMG Halpin, M Miravitlles, N Metzdorf… - International journal of …, 2017 - Taylor & Francis
Severe exacerbations of COPD, ie, those leading to hospitalization, have profound clinical
implications for patients and significant economic consequences for society. The prevalence …

Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary

CF Vogelmeier, GJ Criner, FJ Martinez… - American journal of …, 2017 - atsjournals.org
This Executive Summary of the Global Strategy for the Diagnosis, Management, and
Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 …

[HTML][HTML] Mepolizumab for eosinophilic chronic obstructive pulmonary disease

ID Pavord, P Chanez, GJ Criner… - … England Journal of …, 2017 - Mass Medical Soc
Background Patients with chronic obstructive pulmonary disease (COPD) with an
eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal …

Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease …

S Pascoe, N Locantore, MT Dransfield… - The lancet Respiratory …, 2015 - thelancet.com
Background The short-term benefits of inhaled corticosteroids for patients with chronic
obstructive pulmonary disease (COPD) are greater in patients with evidence of eosinophilic …

Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the …

H Watz, K Tetzlaff, EFM Wouters, A Kirsten… - The lancet Respiratory …, 2016 - thelancet.com
Background Blood eosinophil counts might predict response to inhaled corticosteroids (ICS)
in patients with chronic obstructive pulmonary disease (COPD) and a history of …

FULFIL trial: once-daily triple therapy for patients with chronic obstructive pulmonary disease

DA Lipson, H Barnacle, R Birk, N Brealey… - American journal of …, 2017 - atsjournals.org
Rationale: Randomized data comparing triple therapy with dual inhaled corticosteroid
(ICS)/long-acting β2-agonist (LABA) therapy in patients with chronic obstructive pulmonary …

[HTML][HTML] Withdrawal of inhaled glucocorticoids and exacerbations of COPD

H Magnussen, B Disse… - … England Journal of …, 2014 - Mass Medical Soc
Background Treatment with inhaled glucocorticoids in combination with long-acting
bronchodilators is recommended in patients with frequent exacerbations of severe chronic …

Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial

S Pascoe, N Barnes, G Brusselle… - The Lancet …, 2019 - thelancet.com
Background Previous studies have highlighted a relationship between reduction in rate of
exacerbations with therapies containing inhaled corticosteroids (ICS) and baseline blood …

Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD

ID Pavord, S Lettis, N Locantore, S Pascoe, PW Jones… - Thorax, 2016 - thorax.bmj.com
Objective We performed a review of studies of fluticasone propionate (FP)/salmeterol
(SAL)(combination inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA)) in patients …