B cells and antibodies in multiple sclerosis pathogenesis and therapy

M Krumbholz, T Derfuss, R Hohlfeld… - Nature Reviews …, 2012 - nature.com
B cells and antibodies account for the most prominent immunodiagnostic feature in patients
with multiple sclerosis (MS), namely oligoclonal bands. Furthermore, evidence is …

Multiple sclerosis: molecular mechanisms and therapeutic opportunities

D Miljković, I Spasojević - Antioxidants & redox signaling, 2013 - liebertpub.com
The pathophysiology of multiple sclerosis (MS) involves several components: redox,
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …

[HTML][HTML] B cells are multifunctional players in multiple sclerosis pathogenesis: insights from therapeutic interventions

N Claes, J Fraussen, P Stinissen, R Hupperts… - Frontiers in …, 2015 - frontiersin.org
Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS)
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …

[HTML][HTML] Deciphering the role of B cells in multiple sclerosis—towards specific targeting of pathogenic function

K Lehmann-Horn, S Kinzel, MS Weber - International journal of molecular …, 2017 - mdpi.com
B cells, plasma cells and antibodies may play a key role in the pathogenesis of multiple
sclerosis (MS). This notion is supported by various immunological changes observed in MS …

[HTML][HTML] Dimethyl fumarate induces a persistent change in the composition of the innate and adaptive immune system in multiple sclerosis patients

G Montes Diaz, J Fraussen, B Van Wijmeersch… - Scientific reports, 2018 - nature.com
The effects of dimethyl fumarate (DMF) on the immune system in multiple sclerosis (MS) are
not completely elucidated. In this study, an extensive immunophenotypic analysis of innate …

Fingolimod treatment promotes regulatory phenotype and function of B cells

B Grützke, S Hucke, CC Gross… - Annals of clinical …, 2015 - Wiley Online Library
Objective To evaluate the influence of Fingolimod treatment on B‐cell subset composition
and function in multiple sclerosis patients and its potential clinical relevance. Methods …

Effector and regulatory B cells in multiple sclerosis

E Staun-Ram, A Miller - Clinical immunology, 2017 - Elsevier
The role of B cells in the pathogenesis of Multiple Sclerosis (MS), an autoimmune
neurodegenerative disease, is becoming eminent in recent years, but the specific …

Seeking balance: Potentiation and inhibition of multiple sclerosis autoimmune responses by IL-6 and IL-10

SJ Ireland, NL Monson, LS Davis - Cytokine, 2015 - Elsevier
The cytokines IL-6 and IL-10 are produced by cells of the adaptive and innate arms of the
immune system and they appear to play key roles in genetically diverse autoimmune …

B cells in MS and NMO: pathogenesis and therapy

M Krumbholz, E Meinl - Seminars in immunopathology, 2014 - Springer
B linage cells are versatile players in multiple sclerosis (MS) and neuromyelitis
optica/neuromyelitis optica spectrum disorder (NMO). New potential targets of …

Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD

G John-Schuster, K Hager, TM Conlon… - … of Physiology-Lung …, 2014 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in
lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS) …