Medicinal plants have been used for years as a source of food, spices, and, in traditional
medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family …

Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment.
Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of …

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …

The ATP-binding cassette (ABC) transporters are members of a protein superfamily that are
known to translocate various substrates across membranes, including metabolic products …

Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine
anticancer drugs with different modes of action to avoid the development of resistance did …

The ATP‐binding cassette (ABC) transporters are a superfamily of membrane proteins that
are best known for their ability to transport a wide variety of exogenous and endogenous …