Cryopreservation of platelets, at− 80° C with 5–6% DMSO, results in externalisation of
phosphatidylserine and the formation of extracellular vesicles (EVs), which may mediate …

Abstract Background The Netherlands Armed Forces (NLAF) are using− 80° C deep‐frozen
thrombocyte concentrate (DTC) since 2001. The aim of this study is to investigate the effect …

Platelet transfusions are routine procedures in clinical treatment aimed at preventing
bleeding in critically ill patients, including those with cancer, undergoing surgery, or …

More than 100 years ago, Duke transfused whole blood to a patient with thrombocytopenia
to raise the platelet count and prevent bleeding. Since then, platelet transfusions have …

Introduction: Following the first assessment of the effects of safety measures taken against
transfusion-transmitted bacterial infections (TTBI), the Paul-Ehrlich-Institut (PEI) decided to …

Cryopreservation affects platelets' function, questioning their use for cancer patients. We
aimed to investigate the biochemical events that occur over time after thawing to optimize …

Background Manufacturing methods for dimethyl sulfoxide (DMSO)‐cryopreserved platelets
(CPPs) are manual and labor intensive. Thawing and prepare‐for‐transfusion steps are in …

Introduction Cryopreservation at− 80° C in dimethylsulphoxide extends platelet shelf-life
from 7 days to 2 years. Only limited comparative trial data supports the safety and …

Abstract Background The Netherlands Armed Forces have been successfully using deep-
frozen (− 80° C) thrombocyte concentrate (DTC) for the treatment of (massive) bleeding …

Cryopreservation significantly alters the phenotype of platelets; generating distinct
subpopulations, which may influence the formation of platelet leukocyte aggregates (PLA) …