Diabetic neuropathic pain (DNP) is a common, complex, and severe complication of
diabetes. It can lead to increased mortality, lower-limb amputations, and distressing …

Metastasis is the hallmark of failed tumor treatment and is typically associated with death
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …

Calcium overload and ROS overproduction, two major triggers of acute kidney injury (AKI),
are self‐amplifying and mutually reinforcing, forming a complicated cascading feedback …

Mitophagy has a pivotal protective function in the pathogenesis of neurological disorders.
However, the mechanism of its modulation remains elusive, especially in PINK1-mediated …

Early pathogenesis of ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) is
dominated by intracellular calcium overload, which induces oxidative stress, intracellular …

Innate and acquired resistances to therapeutic agents are responsible for the failure of
cancer treatments. Due to the multifactorial nature of resistance, the identification of new …

The current study aims to investigate the therapeutic potential of luteolin (Lut), a naturally
occurring flavonoid found in various medicinal plants, for treating chronic obstructive …

Raised oxidative stress and abnormal redox status are typical features of multiple myeloma
cells, and the identification of the intimate mechanisms that regulate the relationships …

NLRP3 inflammasome activation plays a critical role in inflammation-related disorders. More
small-molecule entities are needed to study the mechanism of NLRP3 inflammasome …

The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER)
causes ER stress and activates the unfolded protein response (UPR). As an adaptive …