Cancer arises through a complex interplay between genetic, behavioral, metabolic, and
environmental factors that combined trigger cellular changes that over time promote …

The transcription factor EB (TFEB) regulates the expression of target genes bearing the
Coordinated Lysosomal Expression and Regulation (CLEAR) motif, thereby modulating …

Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the
underlying mechanism and its pathogenic role remain elusive. We show that autophagy was …

Recent studies have shown that autophagy upregulation can attenuate sepsis-induced
acute kidney injury (SAKI). The tumor suppressor p53 has emerged as an autophagy …

Background: Acute kidney injury (AKI) affects up to 30% of patients undergoing cardiac
surgery, leading to increased in-hospital and long-term morbidity and mortality. Teprasiran is …

Background AKI is a significant public health problem with high morbidity and mortality.
Unfortunately, no definitive treatment is available for AKI. RNA interference (RNAi) provides …

Acute kidney injury (AKI) is characterized by a sudden decrease in renal function and
impacts growing number of people worldwide. RNA interference (RNAi) showed potential to …

Folic acid (FA)-induced acute kidney injury (AKI) is characterized by the disturbance of redox
homeostasis, resulting in massive tubular necrosis and inflammation. Α-lipoic acid (LA), as …

Renal fibrosis is the common feature of all progressive kidney diseases and exerts great
burden on public health worldwide. The maladaptive repair mechanism of tubular epithelial …