Drug candidate and toxicity screening processes currently rely on results from early-stage in
vitro cell-based assays expected to faithfully represent essential aspects of in vivo …

Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical
roles in embryonic development, co-ordinated contraction of excitable cells, tissue …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …

Direct communication between cells, mediated by gap junctions, is nowadays considered as
an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap …

The multiplicity of functions served by intercellular gap junctions is reflected by the variety of
phenotypes caused by mutations in the connexins of which they are composed. Mutations in …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …

Connexins (cx), structural components of gap junction, are believed to play a role in the
regulation of cell proliferation and suppression of the neoplastic phenotype. We used human …

Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

Bone-forming cells are organized in a multicellular network interconnected by gap junctions.
In these cells, gap junctions are formed by connexin43 (Cx43) and connexin45 (Cx45) …