RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …

Guanine-rich DNA sequences that can adopt non–Watson-Crick structures in vitro are
prevalent in the human genome. Whether such structures normally exist in mammalian cells …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional
regulation of gene expression. Much of the knowledge in this area depends on canonical …

Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

Oligonucleotides are designed to target RNA using base pairing rules, but they can be
hampered by poor cellular delivery and nonspecific stimulation of the immune system. Small …

Metastasis-associated lung adenocarcinoma transcript 1 (Malat1/MALAT1, mouse/human),
a highly conserved long noncoding (lnc) RNA, has been linked with several physiological …

The development of small molecules that target RNA is challenging yet, if successful, could
advance the development of chemical probes to study RNA function or precision …