Cardiotoxicity is a major side effect of the chemotherapeutic drug doxorubicin (Dox), which is
further exacerbated when it is combined with trastuzumab, a standard care approach for …

Nanotechnology has been applied extensively in drug delivery to improve the therapeutic
outcomes of various diseases. Tremendous efforts have been focused on the development …

Cancer is a multi-process disease where different mechanisms exist in parallel to ensure
cell survival and constant adaptation to the extracellular environment. To adapt rapidly …

Mesenchymal stem cells (MSCs) have a tumor-homing ability—they accumulate inside
tumors after systemic injection, and may thus be useful as carriers for tumor-targeting …

Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate
pathway. Besides being a precursor of steroid hormones, bile acid, and vitamin D, it is an …

In the present work, lipophilic caffeic and ferulic acid derivatives were synthesized, and their
cytotoxicity on cultured breast cancer cells was compared. A total of six compounds were …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐associated deaths
worldwide. There is a lack of efficient therapy for HCC; the only available first‐line systemic …

The direct interaction of drugs with the cell membrane is often neglected when drug effects
are studied. Systematic investigations are hindered by the complexity of the natural …

Overexpression of IL17RB is associated with poor prognosis and short survival of the breast
cancer patients. IL17RB/IL17B signaling triggers a substantial increase in the cell growth …

Interactions occurring between malignant cells and the stromal microenvironment heavily
influence tumor progression. We investigated whether this cross-talk affects some molecular …