The use of doxorubicin (DOX), one of the most effective antitumor molecules in the treatment
of metastatic breast cancer, is limited by its low tumor selectivity and its severe side effects …

Fluorouracil (5-FU) is a chemotherapeutic drug widely used to treat colorectal cancer. 5-FU
is known to gradually lose its efficacy in treating colorectal cancer following the acquisition of …

Nanoparticles have emerged in the medical field as a technology well suited for the
diagnosis and treatment of various disease states. They have been heralded as efficacious …

Human FASN is the key enzyme required for de novo synthesis of fatty acids. Up-regulated
FASN expression has been reported in various human cancers and was thought to …

Aim. To perform the comparative study both of qualitative and quantitative content of lipids in
parental and drug resistant breast cancer cells. Materials and methods. Parental (MCF-7/S) …

A better elucidation of molecular mechanisms underlying drug-membrane interaction is of
great importance for drug research and development. To date, different biochemical and …

Mechanical properties of biological structures play an important role in regulating cellular
activities and are critical for understanding metabolic processes in cancerous cells and the …

Supported lipid bilayers (SLBs) hold tremendous promise as cellular-mimetic structures that
can be readily interfaced with analytical and screening tools. The incorporation of …

Cellular membranes serve as an epicentre combining extracellular and cytosolic
components with membranous effectors, which together support numerous fundamental …

In our recent studies exploring the biophysical characteristics of resistant cell lipids, and the
role they play in drug transport, we demonstrated the difference of drug-resistant breast …