Driving autophagy–the role of molecular motors

A Nambiar, R Manjithaya - Journal of Cell Science, 2024 - journals.biologists.com
Most of the vesicular transport pathways inside the cell are facilitated by molecular motors
that move along cytoskeletal networks. Autophagy is a well-explored catabolic pathway that …

[HTML][HTML] Molecular dynamics simulations support a multistep pathway for activation of branched actin filament nucleation by Arp2/3 complex

Y Singh, GM Hocky, BJ Nolen - Journal of Biological Chemistry, 2023 - ASBMB
Actin-related protein 2/3 complex (Arp2/3 complex) catalyzes the nucleation of branched
actin filaments that push against membranes in processes like cellular motility and …

F-actin–rich territories coordinate apoptosome assembly and caspase activation during DNA damage–induced intrinsic apoptosis

VL King, KG Campellone - Molecular Biology of the Cell, 2023 - Am Soc Cell Biol
The actin cytoskeleton is a ubiquitous participant in cellular functions that maintain viability,
but how it controls programmed cell death is not well understood. Here we show that in …

WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration

AM Coulter, V Cortés, CJ Theodore… - Molecular Biology of …, 2024 - Am Soc Cell Biol
The actin cytoskeleton is essential for many functions of eukaryotic cells, but the factors that
nucleate actin assembly are not well understood at the organismal level or in the context of …

A non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria.

F Hentzschel, D Jewanski, Y Sokolowski, P Agarwal… - bioRxiv, 2023 - biorxiv.org
The malaria-causing parasite Plasmodium has a complex life cycle involving both vertebrate
and mosquito hosts. Sexual stages or gametocytes are the only stage competent for …

[HTML][HTML] Reconstitution of Arp2/3-Nucleated Actin Assembly with CP, V-1 and CARMIL

OL Mooren, P McConnell, JD DeBrecht, A Jaysingh… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Actin polymerization is often associated with membrane proteins containing capping-protein-
interacting (CPI) motifs, such as CARMIL, CD2AP, and WASHCAP/Fam21. CPI motifs bind …

[HTML][HTML] A Highlights from MBoC Selection: F-actin–rich territories coordinate apoptosome assembly and caspase activation during DNA damage–induced intrinsic …

VL King, KG Campellone - Molecular Biology of the Cell, 2023 - ncbi.nlm.nih.gov
The actin cytoskeleton is a ubiquitous participant in cellular functions that maintain viability,
but how it controls programmed cell death is not well understood. Here we show that in …

[HTML][HTML] Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity

CJ Theodore, LH Wagner, KG Campellone - bioRxiv, 2024 - ncbi.nlm.nih.gov
Autophagy is an intracellular degradation process that maintains homeostasis, responds to
stress, and plays key roles in the prevention of aging and disease. Autophagosome …

[PDF][PDF] A fresh look at an ancient protein: Actin in health and disease

A Gautreau, P Lappalainen… - European Journal of …, 2023 - researchportal.helsinki.fi
Cells are highly dynamic entities, which undergo continuous alterations in their shapes and
rapid re-organization of their inner workings. A key cellular component responsible for these …

The role of p53 cofactor JMY in the regulation of gene expression in human tumours during DNA damage

I Rodriguez Pastrana - 2023 - irep.ntu.ac.uk
The tumour suppressor p53 is a nuclear transcription factor that orchestrates a myriad of
cellular pathways, including cell cycle arrest, DNA repair, and apoptosis in response to …