The ABCA4 protein (then called a “rim protein”) was first identified in 1978 in the rims and
incisures of rod photoreceptors. The corresponding gene, ABCA4, was cloned in 1997, and …

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Retinitis Pigmentosa (RP) is a hereditary retinopathy that affects about 2.5 million people
worldwide. It is characterized with progressive loss of rods and cones and causes severe …

AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

Polyunsaturated fatty acids (PUFAs) include two series of fatty acids: omega-6 and omega-3
series. PUFAs have amphiphatic properties: hydrophilic head and hydrophobic tail. Such …

Abstract Omega-3 (n− 3) polyunsaturated fatty acids (n− 3 PUFAs) have well documented
anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory …

Lipids are emerging as key regulators of membrane protein structure and activity. These
effects can be attributed either to the modification of bilayer properties (thickness, curvature …

Hereditary degenerations of the human retina are genetically heterogeneous, with well over
100 genes implicated so far. This Seminar focuses on the subset of diseases called retinitis …

Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

Background Observational and experimental data suggest that antioxidant and/or zinc
supplements may delay progression of age-related macular degeneration (AMD) and vision …