The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of
blood pressure and body fluid homeostasis and is a mainstay for the treatment of …

The use of a large number of cardiovascular biomarkers, meant to complement the use of
the electrocardiogram, echocardiography cardiac imaging, and clinical symptom …

Novel pharmacologic treatment options reduce mortality and morbidity in a cost‐effective
manner in patients with heart failure (HF). Undisputedly, the effective implementation of …

As a family of hormones with pleiotropic effects, natriuretic peptide (NP) system includes
atrial NP (ANP), B-type NP (BNP), C-type NP (CNP), dendroaspis NP and urodilatin, with NP …

Subtiligase-catalyzed peptide ligation is a powerful approach for site-specific protein
bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Brain natriuretic peptide (BNP) is an important biomarker for patients with heart failure,
hypertension and cardiac hypertrophy. Although it is known that BNP levels are relatively …

Diabetic nephropathy as a deleterious complication of diabetes mellitus and an important
cause of end-stage renal failure is characterized by changes in the molecular and cellular …

Hypertension is considered a major public health issue due to its high prevalence and
subsequent risk of cardiovascular and kidney diseases. Thus, the search for new …

Background Sacubitril/valsartan (S/V) demonstrated significant effects in improving left
ventricular performance and remodeling in patients with heart failure with reduced ejection …