The emerging role of leukemia inhibitory factor in cancer and therapy

C Zhang, J Liu, J Wang, W Hu, Z Feng - Pharmacology & therapeutics, 2021 - Elsevier
Leukemia inhibitory factor (LIF) is a multi-functional cytokine of the interleukin-6 (IL-6)
superfamily. Initially identified as a factor that inhibits the proliferation of murine myeloid …

Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases

J Wang, CY Chang, X Yang, F Zhou, J Liu, Z Feng… - Molecular Therapy, 2023 - cell.com
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 (IL-6)
superfamily. LIF was initially discovered as a factor to induce the differentiation of myeloid …

Leukemia inhibitory factor: an important cytokine in pathologies and cancer

MM Jorgensen, P de la Puente - Biomolecules, 2022 - mdpi.com
Leukemia Inhibitory Factor (LIF) is a member of the IL-6 cytokine family and is expressed in
almost every tissue type within the body. Although LIF was named for its ability to induce …

[PDF][PDF] Emerging perspectives on leukemia inhibitory factor and its receptor in cancer

J Christianson, JT Oxford, CL Jorcyk - Frontiers in Oncology, 2021 - frontiersin.org
Tumorigenesis and metastasis have deep connections to inflammation and inflammatory
cytokines, but the mechanisms underlying these relationships are poorly understood …

The regulation of cyclins and cyclin-dependent kinases in the development of gastric cancer

A Javed, M Yarmohammadi, KS Korkmaz… - International Journal of …, 2023 - mdpi.com
Gastric cancer predominantly occurs in adenocarcinoma form and is characterized by
uncontrolled growth and metastases of gastric epithelial cells. The growth of gastric cells is …

The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights

S Halder, S Parte, P Kshirsagar, S Muniyan… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The dysregulation of leukemia inhibitory factor (LIF) and its cognate receptor (LIFR) has
been associated with multiple cancer initiation, progression, and metastasis. LIF plays a …

Leukaemia inhibitory factor (LIF) inhibits cancer stem cells tumorigenic properties through hippo kinases activation in gastric cancer

L Seeneevassen, J Giraud, S Molina-Castro, E Sifré… - Cancers, 2020 - mdpi.com
Cancer stem cells (CSCs) present chemo-resistance mechanisms contributing to tumour
maintenance and recurrence, making their targeting of utmost importance in gastric cancer …

[HTML][HTML] High expression of bone morphogenetic protein 1 (BMP1) is associated with a poor survival rate in human gastric cancer, a dataset approaches

JH Rafi, T Jafar, MT Pathan, R Reza, S Islam, IJ Sourna… - Genomics, 2021 - Elsevier
Abstract Bone morphogenetic protein 1 (BMP1) is a secreted metalloprotease of the astacin
M12A family of bone morphogenetic proteins (BMPs). BMP1 activates transforming growth …

Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers

S Yu, Q Li, Y Wang, Y Cui, Y Yu, W Li, F Liu… - Experimental cell …, 2021 - Elsevier
Chemotherapy is the preferred clinical treatment for advanced stage gastric cancer (GC)
patients, of which efficacy could be markedly impaired due to the development of …

Role of PGRMC1 in cell physiology of cervical cancer

CC Shih, HC Chou, YJ Chen, WH Kuo, CH Chan… - Life sciences, 2019 - Elsevier
Aims The most frequent cancers among women worldwide. The mortality of cervical cancer
has declined significantly primarily due to the widespread use of Pap smear tests as a …