Systems biology in cardiovascular disease: a multiomics approach

A Joshi, M Rienks, K Theofilatos, M Mayr - Nature Reviews Cardiology, 2021 - nature.com
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

GTRD: an integrated view of transcription regulation

S Kolmykov, I Yevshin, M Kulyashov… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Gene Transcription Regulation Database (GTRD; http://gtrd. biouml. org/)
contains uniformly annotated and processed NGS data related to gene transcription …

The UCSC genome browser database: 2023 update

LR Nassar, GP Barber, A Benet-Pagès… - Nucleic acids …, 2023 - academic.oup.com
Abstract The UCSC Genome Browser (https://genome. ucsc. edu) is an omics data
consolidator, graphical viewer, and general bioinformatics resource that continues to serve …

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Y Perez-Riverol, J Bai, C Bandla… - Nucleic acids …, 2022 - academic.oup.com
Abstract The PRoteomics IDEntifications (PRIDE) database (https://www. ebi. ac. uk/pride/) is
the world's largest data repository of mass spectrometry-based proteomics data. PRIDE is …

[PDF][PDF] Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

M Guilliams, J Bonnardel, B Haest, B Vanderborght… - Cell, 2022 - cell.com
The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …

VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center

B Amos, C Aurrecoechea, M Barba… - Nucleic Acids …, 2022 - academic.oup.com
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB,
https://veupathdb. org) represents the 2019 merger of VectorBase with the EuPathDB …

[PDF][PDF] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

UniProt: the universal protein knowledgebase in 2021

Nucleic acids research, 2021 - academic.oup.com
The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-
quality and freely accessible set of protein sequences annotated with functional information …

A compendium of uniformly processed human gene expression and splicing quantitative trait loci

N Kerimov, JD Hayhurst, K Peikova, JR Manning… - Nature …, 2021 - nature.com
Many gene expression quantitative trait locus (eQTL) studies have published their summary
statistics, which can be used to gain insight into complex human traits by downstream …

Ensembl 2021

KL Howe, P Achuthan, J Allen, J Allen… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Ensembl project (https://www. ensembl. org) annotates genomes and
disseminates genomic data for vertebrate species. We create detailed and comprehensive …