Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms
Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
Ketamine and depression: a narrative review
A Corriger, G Pickering - Drug design, development and therapy, 2019 - Taylor & Francis
Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …
be reduced within several weeks after the start of conventional antidepressants, but …
Neurophysiology of HCN channels: from cellular functions to multiple regulations
C He, F Chen, B Li, Z Hu - Progress in neurobiology, 2014 - Elsevier
Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …
involved in multiple physiological processes.•HCN channels are excellent targets of various …
The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
PC Kandalepas, KR Sadleir, WA Eimer, J Zhao… - Acta …, 2013 - Springer
Abstract β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the β-
secretase that initiates Aβ production in Alzheimer's disease (AD). BACE1 levels are …
secretase that initiates Aβ production in Alzheimer's disease (AD). BACE1 levels are …
Target deconvolution studies of (2R, 6R)-hydroxynorketamine: an elusive search
J Bonaventura, JL Gomez, ML Carlton, S Lam… - Molecular …, 2022 - nature.com
The off-label use of racemic ketamine and the FDA approval of (S)-ketamine are promising
developments for the treatment of depression. Nevertheless, racemic ketamine and (S) …
developments for the treatment of depression. Nevertheless, racemic ketamine and (S) …
h-Channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex
Gene expression studies suggest that differential ion channel expression contributes to
differences in rodent versus human neuronal physiology. We tested whether h-channels …
differences in rodent versus human neuronal physiology. We tested whether h-channels …
Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders
B Santoro, MM Shah - Annual review of pharmacology and …, 2020 - annualreviews.org
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
Genome-wide association of endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study
Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels
L Sartiani, G Mannaioni, A Masi, MN Romanelli… - Pharmacological …, 2017 - ASPET
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …
members of the voltage-gated pore loop channels family. They show unique features: they …
HCN2 channels in cholinergic interneurons of nucleus accumbens shell regulate depressive behaviors
J Cheng, G Umschweif, J Leung, Y Sagi, P Greengard - Neuron, 2019 - cell.com
Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) have been implicated in
drug addiction, reward, and mood disorders. However, the physiological role of ChIs in …
drug addiction, reward, and mood disorders. However, the physiological role of ChIs in …