Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders
characterized by impaired social interaction and communication, and restricted, repetitive …

Research over the last two decades has established ketamine as a safe, effective, fast-
acting, and sustained antidepressant that significantly reduces adverse symptoms …

Chronic stress can be a precipitating factor in the onset of depression. Lentiviral-mediated
knockdown of HCN1 protein expression and reduction of functional I h produce …

Autism spectrum disorder (ASD) is a common neuropsychiatric disorder, which is
characterized by impairment in social interaction and cognitive behaviors. However, there is …

Neuroinflammation is consistently found in many neurological disorders, but whether or not
the inflammatory response independently affects neuronal network properties is poorly …

Background Post-traumatic stress disorder (PTSD) is commonly associated with concurrent
anxiety and depression symptoms, and reduce the expression of the Brain-Derived …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed
throughout the mammalian central nervous system (CNS). These channels have been …

Ion channels operate in intact tissues as part of large macromolecular complexes that can
include cytoskeletal proteins, scaffolding proteins, signaling molecules, and a litany of other …

Hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channels are
proposed to be critical for cognitive function through regulation of synaptic integration …

Major depressive disorder (MDD) is a prevalent psychiatric condition with limited therapeutic
options beyond monoaminergic therapies. Although effective in some individuals, many …